Effect of calcitriol pulse therapy on maintenance hemodialysis patients 'microinflammation and oxidative stress / 中国基层医药

ABSTRACT

Objective To investigate the effect of calcitriol pulse therapy on maintenance hemodialysis patients'microinflammation and oxidative stress.Methods The clinical data of 106 patients with maintenance hemo-dialysis were retrospectively analyzed.106 patients were randomly divided into two groups,each group had 53 cases. The observation group was treated with high dose pulse oral calcitriol therapy(2.0μg,twice a week),while the control group received conventional calcitriol therapy (0 .5 μg ,qd ).Both two groups were treated for 12 weeks.Then,the levels of iPTH,serum calcium and phosphorus,microinflammation and oxidative stress before and after treatment were compared.Results There was no difference between the two groups in iPTH indicators(t =0.354,P >0.05).After treatment,the levels of iPTH,hs -CRP,IL -6,TGF -β1,MDA,MPO in both two groups all decreased(t =7.678, 7.417,13.663,25.709,16.114,9.940,all P 0.05;t =0.777,1.310, 1.210,1.957,all P >0.05 ),which of the observation group were significantly higher than the control group in 12 weeks(t =2.805,P =0.006;t =3.070,P =0.002).Conclusion For treatment of patients with maintenance hemodialysis,calcitriol pulse therapy can reduce systemic microinflammatory response and enhance antioxidant capacity.