Effects of bisphosphonates on the expression of Bcl-2, Bax and Caspase-3 in condylar cartilage of osteoporosis rats / 中国组织工程研究

ABSTRACT

RESULTS AND CONCLUSION:(1)The number of apoptotic cels in rat condylar cartilage and subcondylar region the sham operation group < the treatment group < the model group (alP< 0.05). (2)Expression of Bcl-2 The trend of the model group was lower than that in the sham operation group, although there was no statisticaly significant difference between the two groups; Bcl-2 expression in the treatment group was statisticaly higher compared to the model group (P< 0.05).(3)Expression of Bax and Caspase-3 The expression levels of Bax and Caspase-3 were higher in the model group than in the sham operation group (alP< 0.05), while Bax and Caspase-3 expression was lower in the treatment group than that in the model group (alP< 0.05). The results suggested that bisphophonates can regulate apoptosis in condylar cartilage from osteoporosis rats by changing the expression of Bcl-2, Bax and Caspase-3.