The role of zinc ifnger protein A20 in immune regulation of dendritic cells and in the pathogenesis of inlfammatory bowel disease / 临床儿科杂志

ABSTRACT

Ubiquitin plays a vital role in both protein degradation and many kinds of cellular functions, such as DNA damage repair, cell cycle regulation, cell growth and immune system function.Ubiquitin modiifed enzyme zinc ifnger protein A20 is considered to be an important gateway for the regulation of immune and inlfammatory responses, which is a key negative regulator in NF-κB signaling pathway. Dendritic cell (DC) is a full-time antigen presenting cell that identifies inflammatory response or pathogenic microorganism by multiple receptors, and is a key moderator for immunity homeostasis. Researches in recent years showed that A20 plays an important role in regulating the function of DC, which may take part in the occurrence and development of inlfammatory bowel disease. In this article, the regulation of A20 in the immunoregulation of DC and its function on the pathogenesis of inlfammatory bowel disease were reviewed.