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Uncertainty Evaluation of the Determination of Lamotrigine in Human Plasma by LC-MS/MS / 中国药师
China Pharmacist ; (12): 854-858, 2016.
Artículo en Chino | WPRIM | ID: wpr-493918
ABSTRACT

Objective:

To evaluate the uncertainty in the determination of lamotrigine(LTG)in human plasma by LC-MS/ MS.

Methods:

The uncertainty sources in the determination of LTG were analyzed and the uncertainty was evaluated and combined. Re-sultsThe expanded uncertainty of LTG at low(0. 050 4 μg· ml - 1 )and high(1. 27 μg· ml - 1 )concentrations was 0. 005 18 μg· ml - 1 and 0. 066 4 μg· ml - 1 ,respectively(P = 95% ,k = 2).

Conclusion:

The uncertainty in the determination of LTG in human plasma by LC-MS/ MS is mainly caused by the protein precipitation recovery,matrix effect and sample preparation at low concentration, and by the matrix effect,sample preparation and repeatability at high concentration.

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Idioma: Chino Revista: China Pharmacist Año: 2016 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Idioma: Chino Revista: China Pharmacist Año: 2016 Tipo del documento: Artículo