The Effects of Topical Cyclosporin A on Glaucoma Drainage Implant Surgery in Rabbits

ABSTRACT

To assess the effects of topical cyclosporin A(Csa) on the function of fibrous capsule and fibroblast proliferation after glaucoma drainage implant surgery in rabbits, we compared intraocular pressure(IOP), outflow resistance through the capsule and fibroblast density in capsule and fibroblast density in capsule among three groups group A(12 eyes) that received implant surgery only, group B(11eyes) trated with topical 2% CsA twice a day for 2 weeks after implant surgery, and group C(14 eyes) with intraoperative subcon-junctival soaking of 2% CsA for S minutes and postoperative topical 2% CsA twice a day for 2 weeks. There was significant postoperative IOP decreases at 2, 4 and 8 weeks in group B(7.3 +/- 2.0. 7.1 +/- 1.7, and 6.6 +/- 1.8 mmHg, respectively) and group C(7.8 +/- 2.6, 7.1 +/- 1.7, and 6.8 +/- 1.6 mmHg, respectively) compared with group A(5.1 +/- 1.7, 5.0 +/- 1.0, and 4.8 +/- 1.5 mmHg, respectively)(p0.05 for each). Fibroblast density was not significantly lower in group B and Group C than in group A(n=3, p=0.08). These results suggest adjunctive topical CsA may enhance the effectiveness of glaucoma drainage implant surgery.