Determination of Fenbendazole and Praziquantel in Compound Fenbendazole Tablets by HPLC / 中国药师
China Pharmacist
;
(12): 1011-1013, 2016.
Artículo
en Chino
| WPRIM
| ID: wpr-493966
ABSTRACT
Objective:
To develop an HPLC method for the determination of fenbendazole and praziquantel in compound fenbendazole tablets.Methods:
An InertSustain? C18 column(250 mm × 4. 6 mm,5 μm)was used. The mobile phase was acetonitrile-phosphate buffer(pH = 3)(48 ∶52)and the flow rate was 1. 0 ml·min-1 . The detection wavelength was 214 nm,the column temperature was 30 ℃ and the sample size was 10 μl.Results:
The linear range of fenbendazole and praziquantel was 4. 545- 63. 630 μg·ml -1(r = 0. 999 9)and 0. 225- 3. 150 μg·ml-1(r = 0. 999 9),respectively. The average recovery was 101. 09%(RSD = 0. 28% ,n = 9)and 99. 47%(RSD = 0. 78% ,n = 9),respectively.Conclusion:
The method is simple,fast, accurate and applicable in the determination of fenbendazole and praziquantel in compound fenbendazole tablets.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
China Pharmacist
Año:
2016
Tipo del documento:
Artículo
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