The role of growth factors in the repair of skeletal muscle injury / 中国组织工程研究

ABSTRACT

BACKGROUND:Growth factors involved in the regulation of cel ular processes play an important role in the wound healing and tissue regeneration. OBJECTIVE:To elaborate the role of a variety of cel ular processes involving growth factors in the repair of skeletal muscle injury, and to provide the references for the treatment and rehabilitation strategies, and the synthesis of biomaterials with growth factor for the skeletal muscle after injury. METHODS:A computer-based online search was conducted in PubMed, Mendeley, Google Scholar, and CNKI databases from 1995 to November 2015 to screen the relevant literatures using the keywords“skeletal muscle, damage repair, insulin-like growth factor, epidermal growth factor, growth factor”. Data screening, processing, and summary were performed. RESULTS AND CONCLUSION:Fifty-one eligible literatures were included. Exercise training promotes the repair and regeneration of the injured skeletal muscle cel s and the recovery of the function by activating satel ite cel s in the sarcolemma and basement membrane to produce the numerous myoblasts. The repair involves the complex biological process regulated by growth factors. Exogenous growth factors up-regulate the mRNA expression of endogenous growth factors, stimulate the proliferation of the myoblasts, accelerate the fusion between myotubes and muscle fibers, promote the repair of skeletal muscle injury, inhibit the formation of scars, thereby enhancing the healing quality.