Clinical efficacy and safety of saccharomyces boulardii powder combined with montmorillonite powder in treatment of acute diarrhea in children / 中国生化药物杂志

ABSTRACT

Objective To investigate the clinical efficacy and safety of montmorillonite powder combined with saccharomyces boulardii powder in treatment of acute diarrhea in children.Methods A total of 68 children with acute diarrhea from March 2014 to July 2015 in Lishui People’s Hospital were collected and randomly divided into experiment group and control group, with 34 cases in each group.Patients in control group were treated by montmorillonite on the basis of anti-inflammation, fluid infusion, support and other symptomatic treatment; patients in experiment group were treated saccharomyces boulardii powder combined with montmorillonite powder on the base of clinical routine treatment, the course was 6 days.The stool frequency, diarrhea control time, diarrhea total time and incidence of adverse reactions rate of two groups before and after treatment were observed, and the validity and safety were compared.Results After 6 days treatment, the daily stool frequency of experiment group were significantly lower than control group(P<0.05); diarrhea control time and diarrhea total time of experiment group were significantly lower than control group(P<0.05).The clinical efficacy of experiment group was 91.18%,higher than 73.53%of control group (P<0.05).Conclusion Saccharomyces boulardii powder combined with montmorillonite powder on acute diarrhea in children with good clinical efficacy.