Role of nuclear factor-κB signaling pathway in inflammatory lung diseases / 中国药理学与毒理学杂志
Chinese Journal of Pharmacology and Toxicology
;
(6): 762-769, 2016.
Artículo
en Chino
| WPRIM
| ID: wpr-497295
ABSTRACT
Nuclear factor(NF)-κB is widely expressed in various types of tissue cells. Abnormal activation of NF-κB signaling pathway can lead to the initiation and progression of asthma,chronic ob?structive pulmonary disease(COPD)and other lung inflammatory diseases,but inhibition of its activity can effectively alleviate the occurrence and development of these diseases. In this paper ,we review biological characteristics of NF-κB,role of NF-κB signaling in asthma,COPD and other inflammatory lung diseases,and potential application of NF-κB inhibitors in clinical treatment of these inflammatory lung diseases. It will provide a valuable reference for further study on pathogenesis,prevention,and control of lung inflammatory diseases.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Chinese Journal of Pharmacology and Toxicology
Año:
2016
Tipo del documento:
Artículo
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