Research progress on the mitochondrial respiratory chain complex Ⅴ in sepsis / 国际儿科学杂志

ABSTRACT

Sepsis is a complex pathophysiological disorder arising from a systemic inflammatory response to infection.It is considered as a major cause of death among critically ill patients in intensive care units.Mitochondrial dysfunction and impaired oxidative phosphorylation have been implicated in the pathogenesis of sepsis.The mitochondrial respiratory chain complex Ⅴ is the key enzyme of oxidative phosphorylation.It is response for ATP synthesis and there is a reduction of complex Ⅴ activity in the early sepsis.However,in the late sepsis,under ischemic conditions, it accounts for significant ATP hydrolysis and the activity is up-regulation.Here,this review focuses on the changes of complex Ⅴ activity,mechanism of regulation and therapy in sepsis.