The relationship between anti-N-methyl-D-aspartate receptor encephalitis and viral encephalitis / 国际儿科学杂志

ABSTRACT

Anti-N-methyl-D-aspartate receptor(NMDAR) encephalitis is a common autoimmune encephalitis.It is recognized gradually in neurological field in recent years.This disease has relatively consistent clinical manifestations.There is a specific anti-NMDAR antibody in cerebrospinal fluid,and a good response to immune therapy.Anti-NMDAR encephalitis is closely associated with viral encephalitis.It is often misdiagnosed as viral encephalitis before it is well understood.Recently,a number of studies have found that virus infection is an important inducing factor of anti-NMDAR encephalitis.The recurrence of the viral encephalitis,especially herpes simplex virus encephalitis,is partially caused by immunological reaction of the central nervous system secondary to virus infection,and the immunological therapy is necessary.The recognition of anti-NMDAR encephalitis and its relationship with viral encephalitis,is very important for the proper treatment and improving the outcome of the patients.