Clinical study of Jiejiu-Hugan decoction combined with polyene phosphatidylcholine capsules on the patients with alcoholic liver disease of liver-qi stagnation and spleen ;deficiency syndrome / 国际中医中药杂志

ABSTRACT

Objective To evaluate the curative effect of Jiejiu-Hugan decoction combined with polyene phosphatidylcholine capsules on the patients with alcoholic liver disease of liver-qi stagnation and spleen deficiency syndrome. Methods A total of 60 ALD patients were divided by random number table into two groupscombined treatment group (35 cases) and conventional treatment group (25 cases). Both groups received treatment according to the changes of symptomatic treatment. Besides, the conventional treatment group was treated with polyene phosphatidylcholine capsules, and combined treatment group was with both polyene phosphatidylcholine capsules and Jiejiu-Hugan decoction. Treatment last for 3 months. The improvement of liver function, blood lipid and the clinical symptoms and signs were observed. Results The total effective rate of the combined treatment group was 94.28%, whilethe conventional treatment group was 68%. The difference between two groups was statistically significant (χ2=7.255, P=0.007). After the treatment, the levels of AST (52.60 ± 9.48 U/L vs. 63.28 ± 19.92 U/L, t=2.964), TBil (18.91 ± 7.23 U/L vs. 27.41 ± 8.53 U/L, t=4.678) in the combined treatment group were significantly lower than that in the conventional treatment group (P<0.01). And TG (2.70 ± 0.52 mmol/L vs. 3.65 ± 0.74 mmol/L, t=4.809), LDL-C (3.56 ± 0.41 mmol/L vs. 4.20 ± 0.40 mmol/L, t=3.810) in the combined treatment group were significantly lower than that in the conventional treatment group (P<0.01). Conclusions Jiejiu-Hugan decoction combined with polyene phosphatidylcholine capsule can effectively improve ALD patients' liver function;reduce the level of blood lipid. The combined treatment curative effect is better than the only western medicine conventional therapy.