Effect of clopidogrel plus aspirin in the treatment of acute ischemic stroke with diabetes mellitus / 中国基层医药

ABSTRACT

Objective To observe clinical curative effect of of aspirin combined with clopidogrel therapy in the treatment of diabetes complicating acute cerebral infarction.Methods 64 patients with diabetes combined with acute cerebral infarction were selected and randomly divided into combined treatment group(32 cases)and control group(32 cases),and the joint treatment group on the basis of conventional treatment was given aspirin and clopi-dogrel treatment,the control group on the basis of conventional treatment was given aspirin therapy.14 days before treatment and after treatment,the nerve function defect score(NIHSS)was evaluated,the Barthel index was used to assess daily life ability of patients.The clinical curative effect and adverse reactions of the two groups were observed. Results Before treatment,NIHSS scores in the combined treatment group and control group were (10.59 ±4.40), (10.63 ±4.35)respectively,Barthel index were (29.40 ±11.50),(28.50 ±12.05)respectively.After treatment, NIHSS scores in the combined treatment group and control group were (5.65 ±1.52),(10.63 ±4.35)respectively, Barthel index were (70.60 ±16.50),(51.65 ±11.45)respectively.NIHSS score was lower than before treatment in the two groups (t =11.48,P <0.01,t =3.10,P <0.01),Barthel index was higher than before treatment(t =44.04, P <0.01;t =27.01,P <0.01),those of the combination therapy group were improved more significantly than the control group (t =12.06,P <0.01;t =19.12,P <0.01).Intracranial hemorrhage and serious adverse reactions were not observed in the two groups.Conclusion The curative effect of aspirin in combination with clopidogrel dual anti-platelet therapy in the treatment of diabetes and acute cerebral infarction was better than aspirin alone,and has better security.