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Relationship between diabetes mellitus and hypothalamic-pituitary-adrenal axis:A systematic review / 中华内分泌代谢杂志
Chinese Journal of Endocrinology and Metabolism ; (12): 668-673, 2016.
Artículo en Chino | WPRIM | ID: wpr-498608
ABSTRACT
Objective To provide objective evidences for early screening of the hypothalamic-pituitary-adrenal(HPA)axis function in diabetic patients, the relationship between HPA axis function and diabetes mellitus was systematically reviewed. Methods PubMed, Ovid, Embase, Web of science Databases were retrieved from articles reporting the relationship between HPA axis function and diabetes mellitus. Meta-analysis were carried out by Stata 12. 0 software for heterogeneity test and data merged among articles for the inclusion and exclusion criteria. Results Our meta-analysis showed the following

results:

Compared with control group, the basal plasma cortisol level in total diabetes group, T1DM group, T2DM group, diabetes patients(with or without chronic complications)combined with hypertension was significantly higher. Compared with control group, postdexamethasone cortisol level was markedly higher in diabetes group. There was no significant difference in 24 h urinary free cortisol(24h UFC)and ACTH levels between diabetes group and control group. Our qualitative evaluation shows the following

results:

the differences of awaking salivary cortisol and cortisol awakening response(CAR)between the two groups were inconsistent among all included studies. Most studies showed that CAR was lower in diabetic patients. Conclusion The present analysis has demonstrated that HPA axis dysfunction exists along with diabetes mellitus, and diabetic comorbidity may further worsen the HPA axis dysfunction.

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Tipo de estudio: Investigación cualitativa / Revisiones Sistemáticas Evaluadas Idioma: Chino Revista: Chinese Journal of Endocrinology and Metabolism Año: 2016 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Tipo de estudio: Investigación cualitativa / Revisiones Sistemáticas Evaluadas Idioma: Chino Revista: Chinese Journal of Endocrinology and Metabolism Año: 2016 Tipo del documento: Artículo