Pseudolaric acid B induces glioblastoma cell line U87 mitotic arrest and apoptosis / 中国病理生理杂志
Chinese Journal of Pathophysiology
;
(12): 1574-1578, 2016.
Artículo
en Chino
| WPRIM
| ID: wpr-498659
ABSTRACT
AIM:
To investigate the effects of pseudolaric acid B on the growth and apoptosis of glioblastoma cell line U87.METHODS:
The cell morphological changes were observed under inverted microscope.The cell viability was evaluated by MTS assay.The cell cycle was analyzed by flow cytometry and Western blot.The cell apoptosis was de-tected by flow cytometry.The changes of apoptosis-related proteins cleaved PARP, caspase-3, procaspase-9 and caspase-8 were determined by Western blot.RESULTS:
Pseudolaric acid B inhibited the viability of U87 cells, arrested U87 cells in mitosis.Apoptosis of U87 cells was induced by pseudolaric acid B.The caspase pathway was activated.CONCLUSION:
Pseudolaric acid B induces glioblastoma cell line U87 mitotic arrest and apoptosis.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Chinese Journal of Pathophysiology
Año:
2016
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS