CLINICAL ANALYSIS OF RETEPLASE COMBINED WITH REDUCED GLUTATHIONE IN THE TREATMENT OF ACUTE ST SEGMENT ELEVATION MYOCARDIAL INFARCTION / 现代医院

ABSTRACT

Objective To observe and analyze the curative effects and safety of reteplase ( rPA) combined with reduced glutathione ( GSH) in the treatment of acute ST segment elevation myocardial infarction.Methods 86 cases of patients with acute ST elevation myocardial infarction in our hospital from April 2013 to April 2014 were ran-domly selected, and divided equally into two groups according to different treatment methods.43 patients in the control group were merely given reteplase for treatment, whereas the other 43 in the experiment group were given com-bined therapy of reteplase and reduced glutathione.The vascular recanalization rate, improvement of effective indicators and incidence of adverse events of patients were compared between the two groups.Results After thrombolysis, the vascular recanalization rate of the experiment group in different time points (2h, 4h and 6 h after thrombolysis) showed no significant difference compared with that of the control group (p>0.05).After the treatment, the effective indicators of the two groups both significantly improved, and the experiment group improved more significantly than the control group (p<0.05, p<0.01).The incidence of adverse events of the experiment group was significantly lower than that of the control group (p<0.05).Conclusion Reteplase combined with reduced glutathione is of sig-nificant curative effect in the treatment of STEMI, which can effectively improve the cardiac function.It is of higher security but with lower incidence of adverse events.