Analysis of chemical composition and evaluation of antigenotoxic, cytotoxic and antioxidant activities of essential oil of Toddalia asiatica (L.) Lam
Asian Pacific Journal of Tropical Biomedicine
;
(12): 1276-1279, 2012.
Artículo
en Chino
| WPRIM
| ID: wpr-500354
ABSTRACT
Objective:
To analyse the chemical composition of essential oil isolated from the leaves ofToddalia asiatica (L.) Lam. and to test its bioactive properties.Methods:
Gas chromatography-mass spectrometry (GC/MS) analysis and antigenotoxicity, cytotoxicity and antioxidant studies of isolated oil.Results:
GC-MS analysis of oil revealed the presence of 42 compounds. The major compound in the oil was β-phellandrene (21.35%). DNA protecting activity of oil was considerably significant against H2O2 induced genotoxicity in human lymphocytes. Concentration of oil needed to protect 50% of DNA was calculated as 100 μg/mL. Cytotoxicity of oil against breast (MCF-7) and colorectal (HT-29) cancer cells were observed with the IC50 value of (7.80±0.03) μg/mL and (100.00±0.16) μg/mL respectively. Considerable DPPH free radical, hydroxyl radical scavenging, iron chelation and inhibition of lipid peroxidation activities of oil were also studied.Conclusions:
The results of the present study clearly indicate oil could be a promising candidate for food and drug preparation.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Asian Pacific Journal of Tropical Biomedicine
Año:
2012
Tipo del documento:
Artículo
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