Clinical Observation of Aidi Injection Combined with Oxaliplatin and Tegafur Gimeracil Oteracil Potassium in the Treatment of Advanced Colorectal Cancer / 中国药房

ABSTRACT

OBJECTIVE:To observe the efficacy and safety of Aidi injection combined with oxaliplatin and tegafur gimeracil oteracil potassium in the treatment of advanced colorectal cancer. METHODS:100 patients with advanced colorectal cancer were ran-domly divided into control group and observation group. Control group was treated with Tegafur gimeracil oteracil potassium cap-sule,body surface area1.50 m2,60 mg,it was orally tak-en after breakfast and dinner d1-28,the drug was stopped for 14 d after 28 d treatment+oxaliplatin 85-130 mg/m2 adding into 500 ml of 5% Glucose injection by intravenous infusion for 2 h. Observation group was additionally treated with Aidi injection 100 ml add-ing into 500 ml of 5% Glucose injection by intravenous infusion,once a day,d1-7,which was repeated every 14 d and was twice. The clinical efficacy,toxicity reactions,improvement of life quality and one-year survival rates in the two groups were observed. RESULTS:There was no statistically significant difference in the total effective rate between 2 groups (P>0.05). The improve-ment rate of life quality and one-year survival rate in the observation group were significantly higher than control group,the inci-dence rates of granulocytopenia,platelet decline,oral ulcer and peripheral neurotoxicity in observation group were significantly low-er than control group, there was significant difference between 2 groups (P<0.05). CONCLUSIONS:The life qnality and one-year surviral rate of Aidi injection combined with oxaliplatin and tegafur gimeracil oteracil potassium is better than only oxalipl-atin combined with tegafur gimeracil oteracil potassium in the treatment of advanced colorectal cancer,with better safety.