Efficacy of Mecobalamin versus α-Lipoic Acid in the Treatment of Diabetic Peripheral Neuropathy:a Me-ta-analysis / 中国药房

ABSTRACT

OBJECTIVE:To systematically review the efficacy of mecobalamin versus α-lipoic acid in the treatment of DPN, and to provide evidence-based reference for clinical treatment. METHODS:Retrieved from Medline,EMBase,PubMed,Cochrane Library,CJFD,VIP and Wanfang database,randomized controlled trials (RCT) about mecobalamin (test group) vs. α-lipoic acid (control group)in the treatment of DPN were collected. After quality evaluation and data extraction,Meta-analysis was performed by using Rev Man 5.2 statistics software. RESULTS:A total of 11 RCT were included,involving 940 patients. Results of Me-ta-analysis showed the total effective rate in test group was significantly lower than control group,there were significant difference in 2 group [OR=0.17,95%CI(0.12,0.24),P<0.001]. CONCLUSIONS:The efficacy of α-lipoic acid is better than mecobalamin in the treatment of DPN. Due to the limit of methodological quality and sample size,it remains to be further verified with more rig-orously designed and long-term follow-up of large-scale RCT.