Compatible Stability of Vidarabine Monophosphate for Injection and Aciclovir Injection / 中国药房

ABSTRACT

OBJECTIVE:To investigate the stability of Vidarabine monophosphate for injection combined with Aciclovir injec-tion. METHODS:HPLC method was adopted. The content variations of two drugs in mixture were determined within 8 h at 5 ℃, 25℃,35℃under dark and light. The changes in appearance,property,pH value and insoluble particles(within 24 h)were inves-tigated before and after compatibility. RESULTS:There were no significant changes in appearance and pH value at 5 ℃,25 ℃, 35 ℃ under dark,and insoluble particles were in line with Chinese Pharmacopoeia(2010 edition),and the relative content of vida-rabine monophosphate and aciclovir were above 99%(compared with 0 h)within 8 h. Under the light conditions,as the tempera-ture raised and the extension of storage time,the content of vidarabine monophosphate did not significantly decrease,but that of aciclovir had declined significantly(4 h and after 4 h),while pH value also had a certain degree of rise;the insoluble particles had no obvious change. CONCLUSIONS:The mixture of vidarabine monophosphate and aciclovir in 0.9% Sodium chloride injections is stable under dark conditions within 8 h;it is suggested that the mixture should be used up within 4 h after mixing and protect from light to guarantee the safety of drug use in the clinic.