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Effect of Midkine (MK) on Cultured Spinal Motor Neurons Damaged by Oxidative Stress / 체질인류학회지
Korean Journal of Physical Anthropology ; : 101-107, 1996.
Artículo en Coreano | WPRIM | ID: wpr-50434
ABSTRACT
To evaluate the effect of midkine (MK), neurotrophic factor on cultured mouse spinal motor neuron, NSC-19 which was inhibited by glucose oxidase (GO)-induced oxygen radicals, MTT assay and neurofilament enzymeimmunoassay were carried out after NSC-19 cells were preincubated with various concentrations of midkine for 2 hours prior to exposure of glucose oxidase. The results were as follows 1. MK increased the rate of cell viability and neurofilamental development in a dose-dependent manner on motoneurons inhibited by glucose oxidase-induced oxygen radicals. 2. MTT50 value was 25 mU/ml GO. 3. GO-induced oxygen radicals were toxic on cultured motor neurons in a time and dose-dependent manner. 4. GO-induced oxygen radicals induced the decrease of cells in number and the loss of neurites in cultured mouse spinal motor neurons. From above the results, it is concluded that oxygen radicals are toxic in cultured mouse spinal motor neurons, and selective neurotrophic factors such as MK enhance the viability of motor neurons inhibited by oxygen radicals.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Filamentos Intermedios / Supervivencia Celular / Neuritas / Especies Reactivas de Oxígeno / Estrés Oxidativo / Factor de Crecimiento Nervioso / Glucosa / Glucosa Oxidasa / Neuronas Motoras / Factores de Crecimiento Nervioso Límite: Animales Idioma: Coreano Revista: Korean Journal of Physical Anthropology Año: 1996 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Filamentos Intermedios / Supervivencia Celular / Neuritas / Especies Reactivas de Oxígeno / Estrés Oxidativo / Factor de Crecimiento Nervioso / Glucosa / Glucosa Oxidasa / Neuronas Motoras / Factores de Crecimiento Nervioso Límite: Animales Idioma: Coreano Revista: Korean Journal of Physical Anthropology Año: 1996 Tipo del documento: Artículo