Study on Percutaneous Absorption in vitro of 0.03%Tacrolimus Ointment / 中国药房
China Pharmacy
;
(12): 3051-3053, 2016.
Artículo
en Chino
| WPRIM
| ID: wpr-504862
ABSTRACT
OBJECTIVE:
To study the percutaneous absorption of 0.03% Tacrolimus ointment,and to compare the difference of domestic test preparation and imported reference preparation.METHODS:
Modified Franz diffusion cells were adopted in trans-dermal test in vitro;HPLC-MS method was used to determine permeation amount and rate in vitro,delay time of domestic test preparation and imported reference preparation 0.03%Tacrolimus ointment.RESULTS:
24 h in vitro permeation amount of test and reference preparations were(3 907±1 191)and(3 896±1 064)ng/cm2;permeation rates were 186.7 and 182.9 ng/(cm2·h);de-lay time were 1.95 and 2.00 h,respectively(P>0.05).CONCLUSIONS:
Test preparation shows good percutaneous property,and is similar to reference preparation in penetration absorbency through nude mice skin.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
China Pharmacy
Año:
2016
Tipo del documento:
Artículo
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