Formulation Optimization and in vitro Release Property Study of Methotrexate Thermosensitive Hydrogels / 中国药房
China Pharmacy
;
(12): 3136-3138, 2016.
Artículo
en Chino
| WPRIM
| ID: wpr-504871
ABSTRACT
OBJECTIVE:
To optimize the formulation of Methotrexate thermosensitive hydrogels,and to study the in vitro re-lease property of it.METHODS:
Taking PLGA-PEG-PLGA as matrix and mannitol as viscosity modifiers,Methotrexate thermosen-sitive hydrogels were prepared. Using the absolute value of the deviation of gelation temperature between 35 ℃,its formulation was optimized by orthogonal test using the concentrations of PLGA-PEG-PLGA,methotrexate and mannitol as factors. The dialysis bag method was used to investigate accumulative release rate of Methotrexate thermosensitive hydrogels and methotrexate solution within 336 h in vitro.RESULTS:
The optimal formulation was as PLGA-PEG-PLGA of 20%,methotrexate of 0.10% and mannitol of 0.10%;gelation temperature were 35.1,35.0,35.0℃. The average drug-loading rate was more than 90%. 12 d accumulative re-lease rate was more than 90%(r=3). Methotrexate solution has been substantially completely relased within 240 h. CONCLU-SIONSMethotrexate thermosensitive hydrogels with sustained-release are prepared successfully,and the preparation technology is simple and practical.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
China Pharmacy
Año:
2016
Tipo del documento:
Artículo
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