Decreased Pattern-Recognition Receptor-Mediated Cytokine mRNA Expression in Obese Children With Otitis Media With Effusion
Clinical and Experimental Otorhinolaryngology
; : 7-12, 2014.
Article
en En
| WPRIM
| ID: wpr-50496
Biblioteca responsable:
WPRO
ABSTRACT
OBJECTIVES: To assess innate and humoral immune responses in middle ear effusion of obese pediatric patients with otitis media with effusion (OME). METHODS: We evaluated 219 children with OME, of whom 21 were obese and 198 were non-obese. We compared the expression in middle ear effusion of mRNAs encoding toll-like receptors (TLR) 2, 4, 5, and 9; nucleotide-binding oligomerization domains (NOD) 1 and 2; retinoic acid-inducible gene (RIG)-I; interleukins (IL)-6, -10, and -12; interferon (IFN)-gamma; and tumor necrosis factor (TNF)-alpha mRNAs. We also compared the expression of immunoglobulins IgG, IgA, and IgM and the bacterial detection rate in the two groups. RESULTS: TLR2-mediated expression of IL-6 mRNA, TLR4-mediated expression of IL-6 and IL-10 mRNA, TLR5-mediated expression of IL-6, IL-10, and TNF-alpha mRNA, TLR9-mediated expression of IL-6 mRNA, and NOD2-mediated expression of IL-6, IL-12, and TNF-alpha mRNA were significantly lower in obese than in non-obese children (P0.05). CONCLUSION: Mean body mass index was higher and pattern-recognition receptor-mediated cytokine mRNA expression was lower in obese than in non-obese children with OME.
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WPRIM
Asunto principal:
Otitis
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Otitis Media
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Bacterias
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Otitis Media con Derrame
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Inmunoglobulina A
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Inmunoglobulina G
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Inmunoglobulina M
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Inmunoglobulinas
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ARN Mensajero
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Índice de Masa Corporal
Límite:
Child
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Humans
Idioma:
En
Revista:
Clinical and Experimental Otorhinolaryngology
Año:
2014
Tipo del documento:
Article