Protective effects of neuroglobin in arsenic-induced nervous system injury / 中华地方病学杂志

ABSTRACT

Neuroglobin (Ngb) is a globin with high affinity to oxygen and is specifically expressed in the brain of vertebrates.Many studies show that Ngb's expressions change and it may have protective effects in nervous system injury,such as ischemia/hypoxia.Mechanisms of the Ngb's protective role include free radicals scavenging,anti-oxidative stress,as well as anti-apoptosis.Ngb can also play a transduction signal to increase downstream phosphatidylinositol-3-kinase/protein serine threonine kinase (PI3K/AKT) signal activities.Arsenic exposure can lead to oxidative stress and apoptosis,Ngb may play a protective role in nervous system injury.In this article,we summarized expression changes and protective role of neuroglobin in nervous system injuries,and out looked the protective role of neuroglobin in endemic arsenic poisoning induced nervous system injury.