Pathogenesis of endothelial cell dysfunction in chronic kidney disease: a retrospective and what the future may hold
Kidney Research and Clinical Practice
;
: 76-82, 2015.
Artículo
en Inglés
| WPRIM
| ID: wpr-50612
ABSTRACT
Cardiovascular complications dominate the landscape of chronic kidney diseases (CKD). Endothelial cell dysfunction (ECD) is a well-known culprit of cardiovascular morbidity and it develops in CKD with remarkable frequency. This brief overview of ECD in CKD scans two decades of studies performed in my laboratory, from genetic analyses to proteomic and metabolomics screens. I provide a detailed description of findings related to the premature senescence of endothelial cells, cell transition from the endothelial to mesenchymal phenotype, and stages of development of ECD. Clinical utility of some of these findings is illustrated with data on laser-Doppler flowmetry and imaging in patients with CKD. Some currently available and emerging therapeutic options for the management of ECD are briefly presented.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Fenotipo
/
Envejecimiento
/
Estudios Retrospectivos
/
Flujometría por Láser-Doppler
/
Células Endoteliales
/
Insuficiencia Renal Crónica
/
Metabolómica
Tipo de estudio:
Estudio de etiología
/
Estudio observacional
Límite:
Humanos
Idioma:
Inglés
Revista:
Kidney Research and Clinical Practice
Año:
2015
Tipo del documento:
Artículo
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