Management of Acute Submacular Hemorrhage with Intravitreal Injection of Tenecteplase, Anti-vascular Endothelial Growth Factor and Gas
Korean Journal of Ophthalmology
;
: 192-197, 2016.
Artículo
en Inglés
| WPRIM
| ID: wpr-50643
ABSTRACT
PURPOSE:
To evaluate the visual and anatomical outcomes for neovascular age-related macular degeneration with submacular hemorrhage after intravitreal injections of tenecteplase (TNK), anti-vascular endothelial growth factor (VEGF) and expansile gas.METHODS:
This study was a retrospective clinical case series following 25 eyes of 25 patients. All patients received a triple injection using 0.05 mL TNK (50 µg), 0.05 mL anti-VEGF and 0.3 mL of perfluoropropane gas. Retreatment with anti-VEGF was performed as needed. Preoperative and postoperative best-corrected visual acuity and central retinal thickness were analyzed.RESULTS:
The mean logarithm of the minimum angle of resolution of best-corrected visual acuity improved significantly from 1.09 ± 0.77 at baseline to 0.52 ± 0.60 at 12 months (p < 0.001). The mean central retinal thickness also improved significantly from 545 ± 156 at baseline to 266 ± 107 at 12 months (p < 0.001). A visual improvement of 0.3 logarithm of the minimum angle of resolution unit or more was achieved in 15 eyes (60%). During the 12 postoperative months, an average of 4.04 intravitreal anti-VEGF injections was applied.CONCLUSIONS:
A triple injection of TNK, anti-VEGF, and a gas appears to be safe and effective for the treatment of submacular hemorrhage secondary to neovascular age-related macular degeneration.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Hemorragia Retiniana
/
Angiografía con Fluoresceína
/
Agudeza Visual
/
Enfermedad Aguda
/
Estudios Retrospectivos
/
Estudios de Seguimiento
/
Resultado del Tratamiento
/
Activador de Tejido Plasminógeno
/
Factor A de Crecimiento Endotelial Vascular
/
Tomografía de Coherencia Óptica
Tipo de estudio:
Estudio observacional
/
Estudio pronóstico
Límite:
Anciano
/
Aged80
/
Femenino
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Korean Journal of Ophthalmology
Año:
2016
Tipo del documento:
Artículo
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