Research progress in epigenetic aberrant in classic Hodgkin lymphoma / 实用肿瘤学杂志
Practical Oncology Journal
; (6): 73-77, 2017.
Article
en Zh
| WPRIM
| ID: wpr-507133
Biblioteca responsable:
WPRO
ABSTRACT
The malignant phenotype of classical Hodgkin lymphoma ( cHL) is partly maintained by epige-netic aberrant ,of which consisted mainly abnormal histone methylation and deacetylation .Progress has been made in clinical trials related to the histone deacetylases inhibitors ( HDACis) in cHL.There is a close association noted between the epigenetic aberrants and the immune escape in cHL .DNA methyltransferase ( DNMT) inhibitors, HDACis and immune checkpoint blockade have shown synergistic effects .Further study to improve the cure rate in cHL by combination strategy is of significant importance .
Texto completo:
1
Índice:
WPRIM
Idioma:
Zh
Revista:
Practical Oncology Journal
Año:
2017
Tipo del documento:
Article