Preparation and Characterization of Scutellarin Nanosuspension / 中国药师
China Pharmacist
;
(12): 42-45, 2017.
Artículo
en Chino
| WPRIM
| ID: wpr-508020
ABSTRACT
Objective:
To prepare scutellarin nanosuspension ( SCU-NS) and study the main influencing factors in the prepara-tion.Methods:
The technology parameters were determined, and then the influencing factors of SCU-NS were studied. The optimal formula was confirmed by orthogonal design with zeta potential as the evaluation index.Results:
The optimal formula process was as followsdrug amount was 0. 5 g, Pluronic? F68 amount was 0. 1 g, phospholipid amount was 0. 2 g, SDS amount was 0. 05 g and HPMC E5 amount was 0. 05 g. The average particle size and the zeta potential of SCU-NS was (122 ± 4) nm and ( -25. 5 ± 0. 6) mV, respectively. The result of transmission electron microscope showed that SCU-NS was spherical and uniform, and the dissolution of SCU-NS in 30 min was more than 90%.Conclusion:
Nanosuspension can significantly enhance the dissolution of SCU.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
China Pharmacist
Año:
2017
Tipo del documento:
Artículo
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