Overview of cerebrospinal fluid and blood candidate biomarkers in Parkinson disease / 中国药理学与毒理学杂志

ABSTRACT

Parkinson disease(PD)is a common,progressive and disabling neurodegenerative movement disorder. Diagnosis of PD depends on clinical history and physical examination,but misdi?agnosis is common in early stages because of similar symptoms to other movement disorders. which is why biomarkers are urgently needed to accurately diagnose PD,especially in the early stages of PD, and find new drug targets. This review discusses the curient research of the PD candidate biomarkers from cerebrospinal fluid and blood in terms of PD pathogenesis. We have found that dihy?droxyphenylacetic acid,alpha- synuclein and its related proteins in Lewy bodies,8- hydroxy deoxy?guanosine,uric acid,interleukin and neurotrophic factors are potential biomarkers. They participate in different stages of PD. In order to enhance the accuracy of early diagnosis and efficacy of drugs evalua?tion,we are to use multiple biomarkers rather than a single biomarker,in combination with different biologic pathways of biomarkers,neuroimaging as well as clinical symptoms.