MiR-152 suppresses the proliferation and invasion of NSCLC cells by inhibiting FGF2
Experimental & Molecular Medicine
;
: e112-2014.
Artículo
en Inglés
| WPRIM
| ID: wpr-50915
ABSTRACT
MicroRNAs (miRNAs) regulate the proliferation and metastasis of cancer cells. Here, we showed that miR-152 was downregulated in non-small-cell lung cancer (NSCLC) tissues and cell lines. Overexpression of miR-152 suppressed cell proliferation and colony formation and also limited migration and invasion. Fibroblast growth factor 2 (FGF2) was confirmed as a direct target of miR-152. FGF2 knockdown suppressed cell proliferation, colony formation, migration and invasion, whereas FGF2 overexpression partially reversed the suppressive effect of miR-152. Furthermore, the presence of miR-152 was inversely correlated with FGF2 in NSCLC tissues. Overall, this study demonstrated that miR-152 suppressed the proliferation and invasion of NSCLC cells by downregulating FGF2. These findings provide novel insights with potential therapeutic applications for the treatment of NSCLC.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Regulación Neoplásica de la Expresión Génica
/
Movimiento Celular
/
Factor 2 de Crecimiento de Fibroblastos
/
Carcinoma de Pulmón de Células no Pequeñas
/
MicroARNs
/
Proliferación Celular
/
Pulmón
/
Neoplasias Pulmonares
/
Invasividad Neoplásica
Límite:
Femenino
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Experimental & Molecular Medicine
Año:
2014
Tipo del documento:
Artículo
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