Clinical Value of Serum IL-17 and MMP-7 in Diagnosis of Hepatocellular Carcinoma / 中国医科大学学报

ABSTRACT

Objective To evaluate the significance of serum interleukin-17(IL-17)and matrix metalloproteinase-7(MMP-7)in the diagnosis of hepatocellular carcinoma(HCC). Methods A total of 52 patients with HCC(HCC group),32 patients with liver cirrhosis(LC group)and 36 healthy controls(control group)were enrolled for the study,and all samples were collected from The First Hospital of China Medical University. Serum levels of IL-17 and MMP-7 were determined using ELISA method. The diagnostic performance and their correlation was evaluated. Re-sults Serum levels of IL-17 and MMP-7 in HCC group were significantly higher than those in LC group(all P<0.001)and control group(all P<0.001). Both of them in LC group were higher than control group(all P<0.05). The area under ROC of serum IL-17 and MMP-7 were 0.901 (95%CI0.847-0.954)and 0.845(95%CI0.772-0.918). The sensitivity of serum IL-17 and MMP-7 in the diagnosis of HCC was 90.4%and 86.5%,respectively,and the specificity of the same markers was 77.9%and 76.5%,respectively. Combined detection of the two markers improved sensitivity to 98.7%and specificity to 94.8%. Serum IL-17 was positively correlated to MMP-7(r=0.513,P<0.01). Conclusion IL-17 and MMP-7 are involved in the progress of HCC,and serum IL-17 and MMP-7 may be useful markers in the diagnosis of HCC.