Effect of irbesartan hydrochlorothiazide tablets on essential hypertension and serum TNF-α and IL-6 levels / 中国生化药物杂志

ABSTRACT

Objective To investigate the clinical efficacy of irbesartan hydrochloride and its effect on serum levels of tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6)in patients with essential hypertension.Methods From 86 patients with essential hypertension who were treated in our hospital from July 2014 to September 2016 were randomly divided into experimental group and control group.43 patients in the control group were treated with irbesartan tablets.Group 43 patients were treated with irbesartan hydrochlorothiazide tablets,and the clinical efficacy,blood pressure and serum TNF-α,IL-6 factor and the incidence of adverse reactions were compared between the two groups.Results The effective rate was 93.02％in experimental group the total effective rate control group was 76.74％,the total effective rate of the experimental group was significantly higher than the control group,the difference was statistically significant(P<0.05).Before and after treatment,the systolic and diastolic blood pressure were higher in the experimental group and the control group,and there was no significant difference between the two groups.After eight weeks of treatment,Systolic and diastolic blood pressure were decreased,and the degree of decline in the experimental group was more obvious,the difference between the two groups was significant,statistically significant(P<0.05).There was no significant difference in serum TNF-α and IL-6 between the experimental group and the control group before treatment.After eight weeks of treatment,the serum TNF-α,IL-6 factor decreased,and the degree of decline in the experimental group was more obvious,the difference between the two groups was significant,statistically significant(P<0.05).The incidence of adverse reactions was 2.33％in 43 patients,43 cases of ankle edema in the control group,3 cases of dizziness and headache,2 cases of mild uric acid and two cases of adverse reaction.The incidence of adverse reactions was 16.28％,The incidence of adverse reactions in the experimental group was significantly lower than the control group,the difference was statistically significant(P<0.05).Conclusion The treatment of essential hypertension with irbesartan hydrochloride is obvious,and the serum TNF-α and IL-6 are decreased and the safety is high.