The value of urine albumin,β2-microglobulin and cystatin C in the early diagnosis of diabetic nephropathy / 国际检验医学杂志

ABSTRACT

Objective To investigate the value of Serum cystatin C(CysC),urine albumin(mAlb),and β2-microglobulin(β2-MG) in the early diagnosis of diabetic nephropathy(DN).Methods 64 cases of patients with early DN (DN group),68 diabetic patients without nephropathy (NDN group),and 55 healthy volunteers (control group) in our hospital from January 2013 to December 2014 were selected as study subject.The serum CysC,β2-MG and morning urine mAlb levels of three groups were detected by immunonephelometry,and the energy efficiency of three indexes in DN diagnosis were analyzed.Results The serum CysC,β2-MG and morning urine mAlb levels of DN group were significantly higher than NDN group and control group (P<0.05).The positive rate of serum CysC,β2-MG and morning urine mAlb levels of DN group were 81.3%,53.1% and 76.6%,respectively,which were significantly higher than the positive rate of NDN group (1.5%,2.9%,and 4.4%) (P<0.05).The specificity of serum CysC,β2-MG and morning urine mAlb levels of DN group were 81.3%,53.1%,76.6%.The area under the ROC curve of CysC,β2-MG and morning urine mAlb in DN diagnostic were 0.899,0.751,and 0.861.The diagnostic efficiency of serum CysC was highest.Conclusion The detection of CysC,β2-MG,and morning urine mAlb could be used to DN early diagnosis.The sensitivity,specificity and efficient diagnosis of serum CysC were the best.