The Effect of Korean Red Ginseng on Symptoms and Quality of Life in Chronic Tinnitus: A Randomized, Open-Label Pilot Study
Journal of Audiology & Otology
;
: 85-90, 2015.
Artículo
en Inglés
| WPRIM
| ID: wpr-51192
ABSTRACT
BACKGROUND AND OBJECTIVES:
The major mechanism of inner ear cell damage is the production of reactive oxygen species (ROS). Korean red ginseng (KRG) has an anti-ROS effect; thus we hypothesized that KRG may be of use for the treatment of chronic idiopathic tinnitus. The aim of the study is to investigate clinical outcomes and health-related quality of life (QoL) in chronic tinnitus patients after taking KRG. SUBJECTS ANDMETHODS:
This study was an open-label randomized controlled trial. Sixty-one patients with chronic tinnitus were enrolled and randomized to three groups. The control group was treated for 4 weeks with 160 mg/day Ginkgo biloba extract, and two other groups receiving 1500 mg/day or 3000 mg/day KRG for 4 weeks. Clinical assessments were performed using the tinnitus handicap inventory (THI), Visual Analogue Scale (VAS) and QoL was assessed by Short Form-36 Health Survey (SF-36) questionnaire.RESULTS:
Fifty-nine patients completed the planned protocol. Significant improvements were observed between initial and post-treatment THI scores in patients receiving 3000 mg/day KRG. There was no statistically significant difference between initial and post-treatment VAS scores in all groups. Treatment with 3000 mg/day KRG for 4 weeks significantly improved role emotional and mental health scores in the SF-36 survey.CONCLUSIONS:
These results suggest that KRG may improve tinnitus symptoms and mental wellbeing in chronic tinnitus patients.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Calidad de Vida
/
Acúfeno
/
Proyectos Piloto
/
Salud Mental
/
Encuestas Epidemiológicas
/
Especies Reactivas de Oxígeno
/
Ginkgo biloba
/
Panax
/
Oído Interno
Tipo de estudio:
Ensayo Clínico Controlado
/
Estudio diagnóstico
/
Guía de Práctica Clínica
Límite:
Humanos
Idioma:
Inglés
Revista:
Journal of Audiology & Otology
Año:
2015
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS