Immunomodulatory Roles of PE/PPE Proteins and Their Implications in Genomic Features of Mycobacterium tuberculosis
Journal of Bacteriology and Virology
;
: 272-281, 2015.
Artículo
en Coreano
| WPRIM
| ID: wpr-51198
ABSTRACT
Tuberculosis, caused by Mycobacterium tuberculosis (Mtb), remains a notorious cause of human death worldwide. A deeper understanding of the proline-glutamate (PE) and proline-proline-glutamate (PPE) families, which compromise 10% of the coding regions in the Mtb genome, has uncovered their unique roles in host-pathogen interactions. Further, comparative genomic analysis of different Mtb strains has proposed that Mtb has acquired diverse gene sets that play immunomodulatory roles in host-pathogen interactions. This review delineates the various immunomodulatory roles of PE/PPE antigens and discusses their implications in the development of the improved diagnostic tools and vaccines.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Tuberculosis
/
Vacunas
/
Genoma
/
Interacciones Huésped-Patógeno
/
Inmunomodulación
/
Codificación Clínica
/
Mycobacterium
/
Mycobacterium tuberculosis
Límite:
Humanos
Idioma:
Coreano
Revista:
Journal of Bacteriology and Virology
Año:
2015
Tipo del documento:
Artículo
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