Expression, functions and regulation of PKM2 in tumor cells / 复旦学报(医学版)
Fudan University Journal of Medical Sciences
; (6): 217-223, 2017.
Article
en Zh
| WPRIM
| ID: wpr-512735
Biblioteca responsable:
WPRO
ABSTRACT
M2 type of pyruvate kinase (PKM2) is one of the most important regulatory molecules in glycolysis,which at high level is a major feature of tumor cells.Besides,PKM2 also regulates gene transcription and cell cycle,promoting the formation,invasion and migration of tumors.Meanwhile,PKM2 can beregulated by many transcription factors,oncogene proteins,miRNA and intermediate metabolites.Extensive studies indicated that PKM2 plays an important role in the developmental tumor.In view of the significance of PKM2 in tumor cells,it holds promise for diagnosis and treatment benefits.
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WPRIM
Idioma:
Zh
Revista:
Fudan University Journal of Medical Sciences
Año:
2017
Tipo del documento:
Article