Observation of clinical effect of Xuebijing injection adjuvant therapy for severe lung infection / 中国基层医药

ABSTRACT

Objective To study the clinical effects and mechanism of Xuebijing injection combined with antibiotics in the treatment of severe lung infection in ICU.Methods 110 cases of ICU severe lung infection were randomly divided into control group(55 cases) and observation group(55 cases).The control group was administered with cefotaxime sodium and sodium benzene azole penicillin,while the observation group was co-administered with Xuebijing injection and cefotaxime sodium,sodium benzene azole penicillin.All treatment lasted for 7 days.Meanwhile,the serum levels of C-reactive protein (CRP),TNF-α,IL-6,COX-2 and SOD were measured before and after the therapy.Results After treatment,the levels of CRP and TNF-α,IL-6 were significantly reduced in the two groups[after treatment CRP,TNF-α,IL-6 levels of the control group(46.50 ± 17.74) ng/L,(339.50 ± 112.61) ng/L,(141.20 ± 42.66) ng/L;and those in the observation group(35.60 ± 16.89) ng/L,(268.20 ± 98.47) ng/L,(118.70 ± 39.81) ng/L;the control groupt =7.329,9.682,6.038;the observation groupt =11.012,14.335,14.335,all P ＜ 0.01],and the reduced amplitude of the observation group was significantly lower than that of the control group (t =3.300,P ＜ 0.01).The serum levels of COX-2 and SOD were significantly reduced [after treatment COX-2 and SOD levels of the control group(189.50 ± 34.52) ng/L,(203.60 ± 67.26) U/mL;those of the observation group(118.20 ± 25.36) ng/L,(162.30 ± 59.78) U/mL;COX-2the control groupt =15.021,P ＜ 0.01;the observation groupt =32.931,P ＜ 0.01;SODthe control group,t =4.183,P ＜ 0.01;the observation group,t =7.682,P ＜0.01],and the reduced amplitude of the observation group was significantly lower than that of the control group(t =3.404,P ＜0.01).Conclusion Xuebijing injection combined with antibiotics in the treatment of severe lung infection in ICU has good effects,which is due to the inhibition of COX-2 and SOD to improve inflammation and oxidative stress damage in cells.