Diagnostic Value and Significance of the HLA-DR53,Anti-Sa and Anti-CCP Antibody Factors Combination in Rheumatoid Arthritis / 现代检验医学杂志
Journal of Modern Laboratory Medicine
;
(4): 78-81, 2017.
Artículo
en Chino
| WPRIM
| ID: wpr-513203
ABSTRACT
Objective To explore the value of human leucocyte antigen-DR53 (HLA-DR53),anti-Sa antibody and anti-cyclic citrullinated peptide antibody(anti-CCP) factors combination in rheumatoid arthritis.Methods 170 patients with rheumatoid arthritis and 50 healthy individuals in the hospital were chosen.The levels of HLA-DR53 by PCR-SSP,the levels of anti-Sa and anti-CCP by ELISA,compared their diagnostic value by consistency analysis and joint detection analysis.Results The sensibility of anti-Sa,HLA-DR53 and anti-CCP in RA were 44.07% (P =0.00,x2 =165.214),68.65 % (P =0.00,x2 =9.837) and 79.45 % (P=0.00,x2=48.028).Consistency analysis in RA,HLA DR53,anti-CCP and anti-Sa highly consistent,OR were 3.94,38.6 and 184.52.The sensitivity and Youden index of anti-CCP were the highest.The sensitivity of anti Sa and anti-CCP parallelled was 88.51 %.The sensitivity of HLA-DR53 and anti-CCP parallelled was 93.56%,and the spe cificity of anti-Sa and anti-CCP of RA were 100%.Conclusion There is a certain correlation between HLA-DR53,anti-Sa and anti-CCP antibody,which are related risk factors of RA,co-detection will improve the diagnosis of RA.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Tipo de estudio:
Estudio diagnóstico
/
Factores de riesgo
Idioma:
Chino
Revista:
Journal of Modern Laboratory Medicine
Año:
2017
Tipo del documento:
Artículo
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