The Expression and Significance of Galectin-3 in COPD and Lung Cancer / 昆明医科大学学报

ABSTRACT

Objective To explore the expression and significance of galectin-3 in COPD and lung cancer.Methods Sixty female SD rats were randomly divided into three groupsCOPD group,lung cancer group and the control group with 20 rats in each group.COPD group was given tracheal injection of lipopolysaccharide and exposed to daily cigarette to establish the model.Lung cancer group was injected with 3,4-benzopyrene-corn mixture.The control group was fed normally.After 20 weeks,plasma galectin-3 concentration was assessed in each group using ELISA method.Results The galectin-3 average concentrations of COPD group,lung cancer group and the control group were (8.63 ± 0.46) ng/mL,(9.15 ± 0.69) ng/mL and (4.47 ± 0.51) ng/mL.The average concentrations in COPD and lung cancer groups were higher than that of the control group with a statistically significant difference (P＜0.05).Conclusion As expressed in COPD and lung cancer,galectin-3 may own a great significance to the occurrence,development and prognosis of COPD and lung cancer.