Antibacterial drugs versus appendectomy for treating simple acute appendicitis:a systematic review / 重庆医学

ABSTRACT

Objective To evaluate the efficacy and safety of antibacterial drugs conservative therapy versus appendectomy for treating simple acute appendicitis(AA).Methods Randomized controlled trials (RCT) on antibacterial drugs conservative therapy versus appendectomy for treating simple AA were retrieved from CBM (1978 June 2015),CNKI (1979-June 2015),Medline (1950-June 2015),Pubmed (1950-June 2015),Embase (1970-June 2015) and Cochrane library (issue 2,2015) by computer.The included RCTs were performed the data extraction according to the criteria of the Cochrane handbook by two researchers.Then the included d/literatures were performed the quality assessment and the extracted effective data were performed the meta analysis.Results Six RCTs were included involving 1510 patients with AA,among them,767 cases were treated with antibacterial drugs and 743 cases were treated with appendectomy.Compared with surgical treatment,the effect rate of antibacterial medication conservative therapy was decreased by 25.00％ (RD=-0.25,95％ CI-0.35--0.14),the recurrence rate was increased by 48.43 times (OR=48.43,95％CI16.94-138.44),the loss time of labor force was shortened by 1.52 d (MD=-1.52,95％ CI-3.02 0.02),but the occurrence rate of complications(RD=-0.06,95％CI-0.15 0.03),pain time(MD=-0.76,95％CI-3.31 1.79),hospital stay time (MD=4.60,95％CI-0.89 10.09) and sick leave time(MD=-2.39,95％CI-5.62-0.84) had no statistical differences between the two kinds of treatment method(P＞0.05).Conclusion Appendectomy may be the gold standard method for treaung simple AA.