Amorolfine Nail Lacquer 5 % Once Weekly in Onychomycosis of Fingers and / or Toes / 대한피부과학회지
Korean Journal of Dermatology
;
: 314-321, 1995.
Artículo
en Coreano
| WPRIM
| ID: wpr-51450
ABSTRACT
BACKGROUND:
Amorolfine is a new topical antifungal drug of the morpholine class has broad spectrum fungicidal activity. Amorolfine nail lacquer 5% is a transungual delivery system which can penetrate well through the nail plate to the infected keratin and remain there for a prolonged period.OBJECTIVE:
The aim of this study is to assess the efficacy and tolerability of 5% amorolfine nail lacquer given once weekly to the patients with onychomycosis.METHODS:
29 patients with onychomycosis affecting not more than 80% of the surface of nail were treated once weekly for up to 9 months with amorolfine nail lacquer 5%. Clinical and mycological examination were performed before treatment and 3, 6, 9 months after start of treatment. Final evaluation was done 3 months after the end of treatment.RESULTS:
Average affected area(%) and average score of clinical signs-thickening, splitting, discoloration-were significantly decreased 3 months after start of treatment. Mycological cure rate was continuously increased according to the treatment duration reaching 75.9% at 3 months after treatment. Overall efficacy assessed by the investgators were cure in 31.0% and improvement in 41.4%. Tolerability, mode and frequency of treatment, and formulation were evaluated as good or excellent by most of the patients.No systemic or local side effect was observed.CONCLUSION:
Amorolfine nail lacquer 5% used once weekly up to 9 months was relatively effective and safe for the treatment of onychomycosis.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Dedos del Pie
/
Onicomicosis
/
Dedos
/
Laca
Límite:
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Dermatology
Año:
1995
Tipo del documento:
Artículo
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