Application of physiologically based pharmacokinetic model in toxicology of nanomaterials:research advances / 中国药理学与毒理学杂志
Chinese Journal of Pharmacology and Toxicology
;
(6): 203-206, 2017.
Artículo
en Chino
| WPRIM
| ID: wpr-514590
ABSTRACT
Physiologically based pharmacokinetic (PBPK) modeling is established based on the information of existing human or other animal anatomy, knowledge of physiology and biochemical data. The model uses mathematical methods to simulate chemicals′process of absorption, distribution, metabolism and excretion in the body, in order to achieve the dose and interspecific extrapolation and to predict the chemical level in the specific organ at the specific time. In studies on toxicology of nanomaterials, the PBPK models in the silver nanoparticles, zinc oxide nanoparticles, titanium dioxide nanoparticles and polymer nanomaterials are gradually established. PBPK modeling can not only provide information on the dynamic change of nanomaterials in the body, but is of great significance for to quantitative evaluation of biological safety of nanomaterials. PBPK modeling will be a hot spot for research in the field of nanotoxicology.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Tipo de estudio:
Estudio pronóstico
Idioma:
Chino
Revista:
Chinese Journal of Pharmacology and Toxicology
Año:
2017
Tipo del documento:
Artículo
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