The effects of aminophylline on graft versus host reaction (GVHR) and the survival of heart allograft in mice / 中国病理生理杂志

ABSTRACT

The effects of aminophylline on xenogenic graft versus host reaction and the survival of heart allograft in mice were investigated. Human T lymphocytes could be separated into two subsets when they were incubated with theophylline in vitro. One subset lost their ability to form E rosette with sheep red blood cells and was called theophylline sensitive T cell (TS). The other one maintained their ability to form E rosette was called thyeophlline resistant T cell (TR). It was shown that TS inhibited and TR enhanced GVHR induced by total T lymphocytes in cyclophosphamide treated rats. Spleen lymphocytes from mice treated with aminophyline showed significant weaker GVHR than that treated with normal saline, suggesting that aminophylline might induce suppressor cells in vivo. The effect of aminophylline on the survival of heart heterotopic allograft was then investigated and the result showed that aminophylline prolonged the survival of transplant significantly.