Study on mutation in V_(79) cells and transformation in NIH/3T3 cells induced by the extract 261-B_2-3 of Alternaria alternata / 中国病理生理杂志
Chinese Journal of Pathophysiology
; (12)1986.
Article
en Zh
| WPRIM
| ID: wpr-515633
Biblioteca responsable:
WPRO
ABSTRACT
The extract 261-B_2-3 of Alternaria alternata isolated from the corn in Linxian county which is an area with high incidence of esophageal cancer induced 6-thioguanine-resistant mutants in V_(79) cells and transformation in NIH/3T3 cells. There is mutation activity in presence or absence of rat-liver-microsome prepar-ations. Treated with a range of eoncentration(32ug/ml, 64ug/ml, 128ug/ml) of the extract, high rate of transformation different from the rate treated by solvent control, is found.The results show that this extract contains direct mutagen. The high infestationincidence of Alternaria alternata in the corn of Linxian county might play an important role in the causation ofesophageal cancer in this area.
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Índice:
WPRIM
Idioma:
Zh
Revista:
Chinese Journal of Pathophysiology
Año:
1986
Tipo del documento:
Article