Localization Forms and Clinical Implication of HBsAg、HBcAg in Liver Tissue with Chronic Hepatitis B / 昆明医科大学学报

ABSTRACT

The study reports on HBsAg and HBcAg in liver tissue samples of 36 patients with chronic hepatitis B were detected with ABC method. Among them 12 cases were HBsAg and/or HBcAg positive (32.4%). We found a high positive rate of replication signs of HBV with chronic active hepatitis indicating active replication of HBV. Also the extent of HBV replication was found parallel to that of active hepatopathy. Those with strong positive stain- ing always have middle or heavy chronic active hepatitis. In our studies active HBV replication and hepatopathy were observed. HBsAg in the liver mainly showed spread form of distribution and HBcAg mainly showed nuclear and cytoplasmic distribution, which was con- sistent with relevant publications. These results indicate that HBV replication is relevant to hepatopathy and its activity