Expressions of TNF Receptors, ICAM-1 and LFA-1 in Lesional Skin of Psoriasis Vulgaris / 中华皮肤科杂志

ABSTRACT

Objective To study the mechanism of tumor necrosis factor(TNF) ? in psoriasis vulgaris. Methods The expressions of 55 kD(p55) and 75 kD(p75) TNF receptors, intercellular adhesion molecule(ICAM) 1, lymphocyte function associated antigen(LFA) 1 in the lesional skin of psoriasis vulgaris were detected by immunohistochemical method. Results Normal skin did not express p55, p75, ICAM 1 and LFA 1, the epidermis of the lesional skin expressed p55, p75 and ICAM 1, the infiltrating mononuclear cells (MNCs) in the dermis expressed p55, p75 and LFA 1 in psoriasis vulgaris. The intensities of staining of the p55 and ICAM 1 on epidermal keratinocytes(EKC) were significantly correlated (r' s=0.704, P0.05). The staining intensity of ICAM 1 on EKC and the number of infiltrating MNCs in the dermis was significantly correlated (r' s=0.724, P