Stress response in rewarming period during cardiopulmonary bypass and precaution / 中华麻醉学杂志

ABSTRACT

Objective To investigate the stress response during cardiopulmonary bypass and the effects of propofol on it Methods Thirty one patients scheduled for valve replacement ,were divided randomly into propofol group (group A,n=16) and control group (group B, n=15) Anesthesia was induced with valium fentanyl vencuronium, was maintained with fentanyl enflurane vencuronium In group A propofol 6 8mg?kg -1 ?h -1 was infused intravenously during CPB MAP,venous plasma concentrations of epinephrine(E) ,norepinephrine(NE) and blood glucose were measured before CPB(T1),cooling to 33℃(T2) and 30℃(T3), stable hypothemia(T4), rewarming to 30℃(T5) and 33℃(T6),and 15 min after CPB(T7) respectively Results In rewarming period, NE and E levels in group B increased significantly (P0 05) The dose of sodium nitroprussid was lower in group A than that in group B, and the dose of dopamine was not different between both groups Conclusions The stress response increases in rewarming stage during CPB ,which can be suppressed by the continuous infusion at anesthetic dose of propofol