Effects of NMDA-R system on pain threshold changes in bilateral feet of rats with one paw inflamed / 中华麻醉学杂志

ABSTRACT

Objective To study the role of NMDA-R system in the differential reaction of pain sense between peripheral inflamed local portion and distal portion Methods One hundred and forty-one adults Wistar rats were randomly divided into 6 groups The pain thresholds (PT) of bilateral feet were measured by paw-pressure technique NMDA receptor antagonist CGP378495mg?kg -1, NMDA receptor agonist NMDA 5mg?kg -1 or NS 1ml was injected intraperitonealy in the first three groups, respectively after one hindpaw was inflamed In the later three groups the same drugs were injected before one hindpaw was inflamed PT of bilateral feet in all groups were measured at virous times Results In the first three groups, PT of inflamed paw decreased ,and of non-inflamed paw increasedmarkedly after inflammation (P0 05), decreased significantly(P0 05), decreased significantly (P