Effects of propofol on glomerular and renal tubular functions / 中华麻醉学杂志

ABSTRACT

Objective To evaluate the effects of propofol on glomerular and renal tubular functionsMethods Twenty-five patients without renal disease were randomly assigned to two groups propofol group(n=13) and enflurane group(n=12), The creatinine, urea nitrogen, uric acid(UA) , ? 2 -microglobulin( ? 2-MG) concentrations in serum and urine were measured before induction of anesthesia, and 1, 2, 3, and 24h after induction Albumin(ALb), immunoglobulin G(IgG), pH, and protein in urine were also examinedResults In both groups , the urine concentrations of ? 2-MG , ALb and IgG were significantly increased following the administrations compared with those before induction of anesthesia (P